circRNA basic information
circBase ID: -
Name: hsa_circ_CASP9
Synonym: circCASP9
Host Gene: -
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human GC cell lines
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: the expression of circCASP9 and circDLG5 in GC tissues and their normal counterparts by using qRT-PCR. Only circCASP9 was revealed to be downregulated in tumor tissues compared with adjacent normal tissues.
Molecular mechanism: circCASP9 significantly inhibited the proliferation, migration, and invasion of GC cells bothin vitroandin vivo. A competing endogenous RNA (ceRNA) network was constructed for the identification of candidate target genes of circCASP9. circCASP9, two miRNAs, and 55 mRNAs were selected for construction of the ceRNA network. We confirmed that circCASP9 can function as a sponge of hsa-miR-589-5p to regulate KANK1 expression, thereby controlling GC progression. Accordingly, we identified that the novel circRNA circCASP9 was differentially expressed between GC tissues and their normal counterparts.
Survival: -
Supported No.:
 1
Description:

circCASP9 can regulate the growth and metastasis of GC via the miR-589-5p/KANK1 axis. The circCASP9/miR-589-5p/KANK1 axis might provide crucial insights for investigating the occurrence and development of GC.
Other information
Title:

Identification and Characterization of the Roles of circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network.

Journal: Oxid Med Cell Longev
Published: 2022/3/25
PubMed ID: 35320976