circRNA basic information
circBase ID: -
Name: hsa_circ_BCL2
Synonym: circRNA-BCL2
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 0080909
DO name: castration-resistant prostate carcinoma
Disease details: castration-resistant prostate cancer
Species: human
Species details: human
Sample type: cell line
Sample type details: human PCa cell lines (C4-2), 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: AMBRA1
Associated microRNA: hsa-miR-198
Biological function: Enzalutamide-resistant (EnzR) CRPC cells can be suppressed by the high-dose-androgen (dihydrotestosterone, DHT).
Molecular mechanism: a high-dose-DHT can suppress the circular RNA-BCL2 (circRNA-BCL2) expression via transcriptional regulation of its host gene BCL2. The suppressed circRNA-BCL2 can then alter the expression of miRNA-198 to modulate the AMBRA1 expression via direct binding to the 3UTR of AMBRA1 mRNA. The consequences of high-dose-DHT suppressed circRNA-BCL2/miRNA-198/AMBRA1 signaling likely result in induction of the autophagic cell death to suppress the EnzR CRPC cell growth. Preclinical studies using in vivo xenograft mouse models also demonstrated that AMBRA1-shRNA to suppress the autophagic cell death can weaken the effect of high-dose-DHT on EnzR CRPC tumors.
Survival: -
Supported No.:
 1
Description:

Together, these in vitro and in vivo data provide new insights for understanding the mechanisms underlying high-dose-DHT suppression of the EnzR CRPC cell growth, supporting a potential therapy using high-dose-androgens to suppress CRPC progression in the future.
Other information
Title:

High-dose-androgen-induced autophagic cell death to suppress the Enzalutamide-resistant prostate cancer growth via altering the circRNA-BCL2/miRNA-198/AMBRA1 signaling.

Journal: Cell Death Discov
Published: 2022/3/24
PubMed ID: 35318303