circRNA basic information
circBase ID: -
Name: hsa_circ_ESRP1
Synonym: CircESRP1
Host Gene: hsa-miR-874-3p
 
 
 
Disease basic information
DO ID:
 1380
DO name: endometrial cancer
Disease details: endometrial cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: EC cell lines (RL95-2, Ishikawa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CPEB4
Associated microRNA: hsa-miR-874-3p
Biological function: circESRP1 was highly expressed in EC tissues and cells and was mainly localized in the cytoplasm. Silencing circESRP1 inhibited the proliferation, migration, and invasion of EC cells in vitro and in vivo; however, overexpression of circESRP1 had the opposite effects.
Molecular mechanism: circESRP1 sponged hsa-miR-874-3p to upregulate CPEB4 expression and ultimately contribute to EC cell proliferation and metastasis. Furthermore, circESRP1 regulated tumour growth in xenograft models.
Survival: -
Supported No.:
 1
Description:

CircESRP1 can interact with miR-874-3p to regulate EMT in endometrial cancer via the miR-874-3p/CPEB4 axis. CircESRP1 may serve as a promising therapeutic target for endometrial cancer.
Other information
Title:

CircESRP1 enhances metastasis and epithelial-mesenchymal transition in endometrial cancer via the miR-874-3p/CPEB4 axis.

Journal: J Transl Med
Published: 2022/3/24
PubMed ID: 35317822