circRNA basic information
circBase ID: -
Name: hsa_circ_ATIC
Synonym: CircATIC
Host Gene: hsa-miR-10-3p
 
 
 
Disease basic information
DO ID:
 1107
DO name: esophageal carcinoma
Disease details: esophageal carcinoma
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: human normal esophageal epithelial cell line (HET_1A), ESCC cell lines (KYSE150, EC109)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-10-3p
Biological function: CircATIC was decreased in ESCA. CircATIC overexpression suppressed cell proliferation, migration and invasion and promoted radiosensitivity and apoptosis in ESCA cells in vitro and repressed tumor formation and radioresistance in vivo.
Molecular mechanism: circATIC served as the sponge for hsa-miR-10b-3p, which directly targeted RHCG. hsa-miR-10b-3p elevation reversed circATIC-mediated effect on ESCA cell progression. Moreover, hsa-miR-10b-3p inhibition suppressed cell growth and metastasis and enhanced radiosensitivity in ESCA cells by targeting RHCG.
Survival: -
Supported No.:
 2
Description:

Overexpression of circATIC hampered ESCA progression and promoted radiosensitivity depending on the regulation of miR-10b-3p and RHCG.
Other information
Title:

CircATIC inhibits esophageal carcinoma progression and promotes radiosensitivity by elevating RHCG through sponging miR-10-3p.

Journal: Thorac Cancer
Published: 2022/3/22
PubMed ID: 35307984