circRNA basic information
circBase ID: -
Name: hsa_circ_ALG1
Synonym: circALG1
Host Gene: hsa-miR-342-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, PDX
Sample type details: normal human colon mucosal epithelial (FHC) cells, HT29, HCT116, SW480, SW620 colon cancer cells
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
UP
Associated gene: PGF
Associated microRNA: hsa-miR-342-5p
Biological function: CircALG1 was highly expressed in both the peripheral blood and tumour tissues of patients with CRC and was closely associated with CRC metastasis. CircALG1 overexpression promoted the migration and invasion of CRC cells, and circALG1 silencing and reduction of the circALG1 m_ixA modification level inhibited CRC cell migration and invasion. In vivo experiments further confirmed the prometastatic role of circALG1 in CRC.
Molecular mechanism: Further mechanistic studies showed that circALG1 upregulated the expression of placental growth factor (PGF) by binding to hsa-miR-342-5p and that m_ixA modification enhanced the binding of circALG1 to hsa-miR-342-5p and promoted its ceRNA function.
Survival: -
Supported No.:
 1
Description:

M6A modification enhances the binding ability of circALG1 to miR-342-5p to promote the ceRNA function of circALG1, and circALG1 could be a potential therapeutic target in and a prognostic marker for CRC.
Other information
Title:

The N(6)-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway.

Journal: Mol Cancer
Published: 2022/3/21
PubMed ID: 35305647