circRNA basic information
circBase ID: -
Name: hsa_circ_VANGL1
Synonym: -
Host Gene: hsa-miR-194
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: K-1, TPC-1, IHH-4
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ZEB1
Associated microRNA: hsa-miR-194
Biological function: high circVANGL1 expression was closely associated with adverse clinical parameters of PTC patients. Our in vitro experiments further indicated that the knockdown of circVANGL1 using siRNA obviously repressed migration, proliferation, EMT, and invasion of PTC cells, while opposite effects were induced by its overexpression.
Molecular mechanism: circVANGL1 could interact with hsa-miR-194 directly in PTC, and serve as a ceRNA to regulate ZEB1 function. Moreover, hsa-miR-194 inhibition markedly abrogated the effects of circVANGL1 knockdown in PTC cells.
Survival: -
Supported No.:
 1
Description:

our results provide convincing evidence that circVANGL1 may exert oncogenic effects in PTC, partly via regulating the miR-194/ZEB1 axis.
Other information
Title:

Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis.

Journal: J Oncol
Published: 2022/3/19
PubMed ID: 35300347