circRNA basic information
circBase ID: hsa_circ_0003340
Name: -
Synonym: circ_0003340
Host Gene: rno-miR-940
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: rat
Species details: rat
Sample type: PDX
Sample type details: Esophageal epithelial cells HET_1A, ESCC cells (Eca_109, TE_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PRKAA1
Associated microRNA: rno-miR-940
Biological function: Upregulated circ_0003340 and PRKAA1, and downregulated miR-940 levels were detected in ESCC. Meanwhile, ESCC progression was apparently restrained by circ_0003340 knockdown in vitro.
Molecular mechanism: Circ_0003340 acted as a ceRNA for miR-940 in regulating ESCC progression and miR-940 was proved to target PRKAA1 to arrest ESCC progression in vitro. Finally, in vivo experiments established that silencing of circ_0003340 slowed tumor growth in vivo.
Survival: -
Supported No.:
 1
Description:

Circ_0003340 downregulation mitigated esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis.
Other information
Title:

Circ_0003340 downregulation mitigates esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis.

Journal: Thorac Cancer
Published: 2022/3/18
PubMed ID: 35297212