circRNA basic information
circBase ID: -
Name: hsa_circ_PSD3
Synonym: -
Host Gene: hsa-miR-25-3p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human kidney tubular epithelial cells (HK-2), ccRCC cell lines (A498, 786O, 769P, Caki-1, ACHN)
circRNA-disease information
Detected method:
Q
M
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-25-3p
Biological function: A qRT-PCR analysis performed on our ccRCC cohorts confirmed the downregulation of circPSD3 in ccRCC tissues and further suggested that a low level of circPSD3 expression was associated with tumor metastasis in patients with ccRCC. Based on the results of functional studies, circPSD3 significantly inhibited cell migration, invasion, and the epithelial-mesenchymal transition (EMT) in vitro and blocked pulmonary metastasis in vivo.
Molecular mechanism: circPSD3 functioned as a competing endogenous RNA for microRNA 25-3p (hsa-miR-25-3p) to regulate F-box and WD repeat domain-containing 7 (FBXW7) expression. Further verification indicated that circPSD3 overexpression restrained an EMT-like phenotype in cells, while hsa-miR-25-3p partially rescued these effects.
Survival: -
Supported No.:
 1
Description:

circPSD3 inhibits tumor metastasis by repressing the miR-25-3p/FBXW7-EMT axis and might be developed as a potential diagnostic and therapeutic target for ccRCC.
Other information
Title:

Downregulation of Circular RNA circPSD3 Promotes Metastasis by Modulating FBXW7 Expression in Clear Cell Renal Cell Carcinoma.

Journal: J Oncol
Published: 2022/3/18
PubMed ID: 35295711