circRNA basic information
circBase ID: hsa_circ_0000064
Name: -
Synonym: Circ_0000064
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 557
DO name: kidney disease
Disease details: diabetic nephropathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HK-2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ROCK1
Associated microRNA: hsa-miR-532-3p
Biological function: Circ_0000064 expression was increased in the serum of DN patients and HG-induced HK-2 cells, and silenced circ_0000064 could relieve HG-induced HK-2 cells injury.
Molecular mechanism: hsa-miR-532-3p could be sponged by circ_0000064, and its overexpression also alleviated HG-induced HK-2 cells injury. Besides, the regulation of circ_0000064 knockdown on HG-induced HK-2 cells injury could be reversed by hsa-miR-532-3p inhibitor. Additionally, ROCK1 was a target of hsa-miR-532-3p, and its expression was inhibited by circ_0000064 knockdown. The inhibition effect of circ_0000064 knockdown on HG-induced HK-2 cells injury also could be reversed by overexpressing ROCK1.
Survival: -
Supported No.:
 3
Description:

circ_0000064 knockdown might alleviate HG-induced HK-2 cells injury via regulating the miR-532-3p/ROCK1 axis, which provided a new perspective for DN treatment.
Other information
Title:

Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis.

Journal: BMC Endocr Disord
Published: 2022/3/17
PubMed ID: 35291991