circRNA basic information
circBase ID: mmu_circ_0001679
Name: -
Synonym: circRNA_0001679
Host Gene: mmu-miR-338-3p
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: acute lung injury
Species: mouse
Species details: mouse
Sample type: cell line, PDX
Sample type details: mouse lung epithelial (MLE)-12 cells
circRNA-disease information
Detected method:
M
Detected method confidence Low
Expression pattern:
UP
Associated gene: DUSP16
Associated microRNA: mmu-miR-338-3p
Biological function: circ_0001679 knockdown attenuated lung pathological changes, reduced pulmonary microvascular permeability, and suppressed inflammation in ALI mice.
Molecular mechanism: circ_0001679 was overexpressed in lipopolysaccharide (LPS)-stimulated MLE-12 cells. circ_0001679 knockdown suppressed apoptosis and proinflammatory cytokine production induced by LPS. Moreover, circ_0001679 bound to mmu-miR-338-3p and mmu-miR-338-3p targeted dual-specificity phosphatases 16 (DUSP16). DUSP16 overexpression reversed the effect of circ_0001679 knockdown in LPS-stimulated MLE-12 cells.
Survival: -
Supported No.:
 1
Description:

circ_0001679 knockdown inhibits sepsis-induced ALI progression through the miR-338-3p/DUSP16 axis.
Other information
Title:

circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury.

Journal: Open Med (Wars)
Published: 2022/3/17
PubMed ID: 35291714