circRNA basic information
circBase ID: hsa_circ_0048856
Name: -
Synonym: Circ_0048856
Host Gene: hsa-miR-193a-5p, hsa-miR-98-5p
 
 
 
Disease basic information
DO ID:
 1324
DO name: lung cancer
Disease details: lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human lung cancer cells (H1650, A549, H1299), normal bronchial epithelial (HBE) cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-193a-5p, hsa-miR-98-5p
Biological function: circ_0048856 silencing re-sensitized DDP-resistant lung cancer cells to DDP, as well as suppressed cell growth and invasion in lung cancer_n vitro_nd_n vivo.
Molecular mechanism: circ_0048856 acted as the sponge for hsa-miR-193a-5p or hsa-miR-98-5p, which targeted ABCC1.
Survival: -
Supported No.:
 1
Description:

circ_0048856 knockdown suppressed tumor growth and reduced DDP resistance in lung cancer by miR-193a-5p/ABCC1 or miR-98-5p/ABCC1 axis, indicating a novel strategy for efficient application of DDP in lung cancer.
Other information
Title:

Circ_0048856 competes with ABCC1 for miR-193a-5p/miR-98-5p binding sites to promote the cisplatin resistance and tumorigenesis in lung cancer.

Journal: J Chemother
Published: 2022/3/16
PubMed ID: 35289739