circRNA basic information
circBase ID: hsa_circ_0014130
Name: -
Synonym: Circ_0014130
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal colorectal cells (NCM460), human colorectal cancer cell lines (HCT116, LoVo)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-197-3p
Biological function: Knocking down circ_0014130 can promote cell apoptosis, inhibit the proliferation of CRC cells, and reduced the IC50 of 5-FU.
Molecular mechanism: Knocking down circ_0014130 can promote cell apoptosis, inhibit the proliferation of CRC cells, and reduced the IC50 of 5-FU.
Survival: -
Supported No.:
 1
Description:

Circ_0014130 modulates 5-FU resistance in CRC by modulating the miR-197-3p/PFKFB3 axis, which is helpful for drug chemotherapy in CRC.
Other information
Title:

Circ_0014130 is involved in the drug sensitivity of colorectal cancer through miR-197-3p/PFKFB3 axis.

Journal: J Gastroenterol Hepatol
Published: 2022/3/16
PubMed ID: 35288979