circRNA basic information
circBase ID: hsa_circ_0064288
Name: -
Synonym: Circ_0064288
Host Gene: hsa-miR-335-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (Huh7, Hep3B, HCCLM3, MHCC97-L), human normal liver epithelial cell line (THLE-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-335-5p
Biological function: High circ_0064288 expression was associated with shorter survival time of HCC patients. It was also revealed that circ_0064288 overexpression remarkably enhanced HCC cell growth and migration, while knockdown of circ_0064288 induced opposite effects.
Molecular mechanism: circ_0064288 could competitively bind with hsa-miR-335-5p thereby up-modulate ROCK1 expression. hsa-miR-335-5p overexpression partly counteracted the effect of circ_0064288 overexpression on HCC cells.
Survival: -
Supported No.:
 1
Description:

Circ_0064288 facilitates HCC cell growth and migration by modulating the miR-335-5p/ROCK1 axis.
Other information
Title:

Circ_0064288 acts as an oncogene of hepatocellular carcinoma cells by inhibiting miR-335-5p expression and promoting ROCK1 expression.

Journal: BMC Cancer
Published: 2022/3/16
PubMed ID: 35287604