circRNA basic information
circBase ID: hsa_circ_0075804
Name: -
Synonym: Circ_0075804
Host Gene: hsa-miR-1287-5p
 
 
 
Disease basic information
DO ID:
 768
DO name: retinoblastoma
Disease details: Retinoblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human RB cell lines (WERI-RB-1, SO-RB50, Y79)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1287-5p
Biological function: Circ_0075804 knockdown repressed RB cell growth, invasion and survival, and hindered tumor development_n vivo.
Molecular mechanism: miR-1287-5p was targeted by circ_0075804, and its repression largely reversed the functional effects of circ_0075804 knockdown. LASP1 was a functional target of hsa-miR-1287-5p. The inhibition of hsa-miR-1287-5p upregulation on RB cell proliferation, survival and invasion was reversed by LASP1 overexpression. Moreover, circ_0075804 knockdown weakened LASP1 expression via increasing hsa-miR-1287-5p.
Survival: -
Supported No.:
 3
Description:

Circ_0075804 promotes LASP1 expression by targeting miR-1287-5p, thus acting as a contributor to RB carcinogenesis.HighlightsCirc_0075804 is overexpressed in RB.Circ_0075804 knockdown inhibits RB cell malignant phenotypes and tumor growth_n vivo.Circ_0075804 regulates RB cell behaviors by targeting miR-1287-5p.MiR-1287-5p affects RB cell behaviors by binding to LASP1.Circ_0075804 regulates LASP1 expression via targeting miR-1287-5p.
Other information
Title:

Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma.

Journal: Curr Eye Res
Published: 2022/3/15
PubMed ID: 35285372