circRNA basic information
circBase ID: hsa_circ_0062558
Name: -
Synonym: Circ_0062558
Host Gene: hsa-miR-876-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Non-cancer cells (MCF-10A), TNBC cells (MDA-MB-468, MCF-7, MDA-MB-231)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-876-3p
Biological function: Downregulation of circ_0062558 inhibited proliferation, migration, invasion, and glutamine metabolism, while enhanced apoptosis of TNBC cells, and silencing of circ_0062558 also inhibited the growth of tumor in vivo.
Molecular mechanism: hsa-miR-876-3p was confirmed as a target of circ_0062558, and circ_0062558 knockdown repressed TNBC cell malignant behaviors by increasing hsa-miR-876-3p. Furthermore, hsa-miR-876-3p inhibited malignant behaviors of TNBC cells by down-regulating SLC1A5, a newly identified target of hsa-miR-876-3p.
Survival: -
Supported No.:
 2
Description:

Circ_0062558 promoted TNBC progression by enhancing proliferation, survival, migration, invasion, and glutamine metabolism via miR-876-3p/SLC1A5 axis, which was helpful for understanding the carcinogenic roles of circ_0062558.
Other information
Title:

Circ_0062558 promotes growth, migration, and glutamine metabolism in triple-negative breast cancer by targeting the miR-876-3p/SLC1A5 axis.

Journal: Arch Gynecol Obstet
Published: 2022/3/15
PubMed ID: 35284960