circRNA basic information
circBase ID: -
Name: hsa_circ_ATRNL1
Synonym: CircATRNL1
Host Gene: hsa-miR-152-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Ovarian cancer cell lines (A2780, SKOV3, SW626), a normal ovarian epithelial cell line (IOSE80)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-152-5p
Biological function: The overexpression of circATRNL1 and circZNF608 inhibits the proliferation and invasion of ovarian cancer cells.
Molecular mechanism: hsa-miR-152-5p was sequestered by circZNF608.
Survival: -
Supported No.:
 1
Description:

In conclusion, circATRNL1 and circZNF608 are two downregulated circRNAs in ovarian cancer and work as tumor suppressors. CircZNF608 may exert antitumor activity in ovarian cancer by binding miR-152-5p, and circATRNL1 may encode a 131 aa protein.
Other information
Title:

CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein.

Journal: Front Genet
Published: 2022/3/15
PubMed ID: 35281849