circRNA basic information
circBase ID: -
Name: hsa_circ_DVL1
Synonym: circDVL1
Host Gene: hsa-miR-412-3p
 
 
 
Disease basic information
DO ID:
 4467
DO name: clear cell renal cell carcinoma
Disease details: clear cell renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: 786-O, Caki-1 cells ACHN cells, 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: PCDH7
Associated microRNA: hsa-miR-412-3p
Biological function: Overexpression of circDVL1 inhibits proliferation, induces G1/S arrest, triggers apoptosis, and reduces migration and invasion in different ccRCC cells_n vitro. Correspondingly, circDVL1 overexpression suppresses ccRCC tumorigenicity in a mouse xenograft model.
Molecular mechanism: circDVL1 serves as a sponge for oncogenic hsa-miR-412-3p, thereby preventing hsa-miR-412-3p-mediated repression of its target protocadherin 7 (PCDH7) in ccRCC cells.
Survival: -
Supported No.:
 1
Description:

Collectively, our results demonstrate that circDVL1 exerts tumor-suppressive function during ccRCC progression through circDVL1/miR-412-3p/PCDH7 axis, and suggest that circDVL1 could be a novel diagnostic and prognositc marker and therapeutic target for ccRCC.
Other information
Title:

Circular RNA circDVL1 inhibits clear cell renal cell carcinoma progression through the miR-412-3p/PCDH7 axis.

Journal: Int J Biol Sci
Published: 2022/3/15
PubMed ID: 35280687