circRNA basic information
circBase ID: hsa_circ_0060731
Name: -
Synonym: Circ_0060731
Host Gene: hsa-miR-21-5p
 
 
 
Disease basic information
DO ID:
 0070227
DO name: intrahepatic cholestasis of pregnancy
Disease details: Intrahepatic cholestasis of pregnancy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HTR8/Svneo cell
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: ESR1
Associated microRNA: hsa-miR-21-5p
Biological function: induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy.
Molecular mechanism: Overexpression of hsa-miR-21-5p significantly reduced the expression of PDCD4 and ESR1 and reduced cell apoptosis. The dual-luciferase experiment showed that both PDCD4 and ERS1 were the target genes of hsa-miR-21-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0060731 mediated miR-21-5p-PDCD4/ESR1 pathway could induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy.
Other information
Title:

Circ_0060731 mediated miR-21-5p-PDCD4/ESR1 pathway to induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy.

Journal: Tissue Cell
Published: 2022/3/14
PubMed ID: 35279605