circRNA basic information
circBase ID: hsa_circ_0001174
Name: -
Synonym: Circ_0001174
Host Gene: hsa-miR-186-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblast cell line (hFOB1.19), OS cell lines (MG63, HOS, U2OS)
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-186-5p
Biological function: circ_0001174 may promote the proliferation, migration, and invasion of OS cells
Molecular mechanism: circ_0001174 may promote the proliferation, migration, and invasion of OS cells
Survival: -
Supported No.:
 1
Description:

Abnormally high expression of circ_0001174 may promote the proliferation, migration, and invasion of OS cells through up-regulating MACC1 by sponging miR-186-5p. These results provide insight into therapeutic targets for preventing and treating OS.
Other information
Title:

Circ_0001174 facilitates osteosarcoma cell proliferation, migration, and invasion by targeting the miR-186-5p/MACC1 axis.

Journal: J Orthop Surg Res
Published: 2022/3/14
PubMed ID: 35279159