circRNA basic information
circBase ID: -
Name: hsa_circ_FADS2
Synonym: circFADS2
Host Gene: hsa-miR-133a
 
 
 
Disease basic information
DO ID:
 0040085
DO name: bacterial sepsis
Disease details: sepsis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human bronchial epithelial cells (HBEpCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-133a
Biological function: circFADS2 overexpression and miR-133a inhibition prominently promoted cell viability. circFADS2 knockdown and miR-133a overexpression inhibited viability (0.36-fold vs. pcDNA3.1; 0.37-fold vs. NC miRNA) and increased apoptosis.
Molecular mechanism: circFADS2 overexpression reduced the effects of hsa-miR-133a on LPS-treated HBEpCs.
Survival: -
Supported No.:
 2
Description:

CircFADS2 is under-expressed in sepsis and may protect lung cells from LPS-induced apoptosis by downregulating miR-133a.
Other information
Title:

CircRNA circFADS2 is under-expressed in sepsis and protects lung cells from LPS-induced apoptosis by downregulating miR-133a.

Journal: J Inflamm (Lond)
Published: 2022/3/14
PubMed ID: 35279129