circRNA basic information
circBase ID: -
Name: hsa_circ_ANKRD42
Synonym: circANKRD42
Host Gene: -
 
 
 
Disease basic information
DO ID:
 850
DO name: lung disease
Disease details: lung fibrosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human fetal lung fibroblast cell line (MRC-5)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Participated in pulmonary fibrosis through the close communication of mechanical stiffness and biochemical signals
Molecular mechanism: The biogenetic circANKRD42 sponged hsa-miR-324-5p to promote the AJUBA expression
Survival: -
Supported No.:
 1
Description:

Our findings supported that circANKRD42 is a promising biomarker and a potential therapeutic target related to cytoskeleton tension for IPF treatment.
Other information
Title:

hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.

Journal: Mol Ther
Published: 2022/3/13
PubMed ID: 35278674