circRNA basic information
circBase ID: hsa_circ_0002945
Name: -
Synonym: Circ_0002945
Host Gene: hsa-miR-431-5p
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: amyloid beta (Abeta)25-35-stimulated SK-N-SH cells, human primary neurons (HPNs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-431-5p
Biological function: Inhibition of circ_0002945 attenuated Abeta25-35-induced cell apoptosis and endoplasmic reticulum stress.
Molecular mechanism: hsa-miR-431-5p was regulated by circ_0002945 and it was responsible for the circ_0002945 function. Moreover, TNFAIP1 was a hsa-miR-431-5p target and circ_0002945 functioned as a ceRNA to control TNFAIP1 expression via hsa-miR-431-5p competition.
Survival: poor
Supported No.:
 2
Description:

Our findings establish circ_0002945 as a crucial regulator of Abeta-induced neuron apoptosis and endoplasmic reticulum stress and uncover a novel circ_0002945/miR-431-5p/TNFAIP1 ceRNA network for the Abeta pathogenic pathway in AD.
Other information
Title:

Circ_0002945 functions as a competing endogenous RNA to promote Abeta(25-35)-induced endoplasmic reticulum stress and apoptosis in SK-N-SH cells and human primary neurons.

Journal: Brain Res
Published: 2022/3/13
PubMed ID: 35278480