circRNA basic information
circBase ID: -
Name: hsa_circ_ITGB6
Synonym: CircITGB6
Host Gene: -
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OC cell lines (OVCAR3, SKOV3, TOV21G, TOV112D, CAOV3)
circRNA-disease information
Detected method:
S
Detected method confidence Low
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circITGB6 overexpression promoted an M2 macrophage-dependent CDDP resistance in both vivo and vitro.
Molecular mechanism: Mechanistic research determined that circITGB6 directly interacted with IGF2BP2 and FGF9 mRNA to form a circITGB6/IGF2BP2/FGF9 RNA-protein ternary complex in the cytoplasm, thereby stabilizing FGF9 mRNA and inducing polarization of TAMs toward M2 phenotype.
Survival: poor
Supported No.:
 1
Description:

This study reveals a novel mechanism for platinum resistance in OC and demonstrates that circITGB6 may serve as a potential prognostic marker and a therapeutic target for patients with OC.
Other information
Title:

CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype.

Journal: J Immunother Cancer
Published: 2022/3/13
PubMed ID: 35277458