circRNA basic information
circBase ID: -
Name: hsa_circ_ZEB1
Synonym: Circ-ZEB1
Host Gene: hsa-miR-199a-3p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HCC cell lines (SMMC-7721, HCC-LM3, MHCC-97H, Huh-7), normal hepatic cell line (HL-7702)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-199a-3p
Biological function: downregulation of circ-ZEB1 reduced HCC cell proliferation and promoted cell apoptosis.
Molecular mechanism: hsa-miR-199a-3p blocked the effect of circ-ZEB1 on HCC. Circ-ZEB1 served as a biomarker of HCC. Circ-ZEB1 promoted the expression of PIK3CA by silencing hsa-miR-199a-3p to affect the progress of HCC.
Survival: poor
Supported No.:
 1
Description:

Circ-ZEB1 promoted the expression of PIK3CA by depleting miR-199a-3p, thereby affecting HCC proliferation and apoptosis.
Other information
Title:

Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma.

Journal: Mol Cancer
Published: 2022/3/13
PubMed ID: 35277182