circRNA basic information
circBase ID: hsa_circ_0003307
Name: hsa_circ_TALDO1
Synonym: -
Host Gene: -
 
 
 
Disease basic information
DO ID:
 7147
DO name: ankylosing spondylitis
Disease details: ankylosing spondylitis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: AS-FLS cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: We found that hsa_circ_0003307 overexpression could promote the activation of the PI3K/AKT pathway and expression of inflammatory cytokines - tumor necrosis factor alpha (TNF-alpha) and TNF-alpha-induced protein 2 (TNFAIP2).
Molecular mechanism: -
Survival: -
Supported No.:
 1
Description:

The expression level of hsa_circ_0003307 was associated with inflammatory response, and it was revealed that hsa_circ_0003307 knockdown could reduce the inflammatory response of AS by regulating the PI3K/AKT pathway.
Other information
Title:

Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway.

Journal: Adv Clin Exp Med
Published: 2022/3/12
PubMed ID: 35275449