circRNA basic information
circBase ID: hsa_circ_0058122
Name: hsa_circ_FN1
Synonym: circ_0058122
Host Gene: hsa-miR-7974
 
 
 
Disease basic information
DO ID:
 10159
DO name: osteonecrosis
Disease details: osteonecrosis
Species: human
Species details: human
Sample type: cell line
Sample type details: human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: IGFBP5
Associated microRNA: hsa-miR-7974
Biological function: The Dex-mediated HUVEC apoptosis was impaired in hsa_circ_0058122-silenced cells and increased in hsa_circ_0058122-overexpressing cells.
Molecular mechanism: hsa_circ_0058122 competitively binds to hsa-miR-7974, which in turn interacts with insulin-like growth factor binding protein 5 (IGFBP5).
Survival: -
Supported No.:
 1
Description:

hsa_circ_0058122/miR-7974/IGFBP5 was proposed to be a key regulatory pathway for SONFH. DEX treatment upregulated hsa_circ_0058122 expression in HUVECs, which sponged miR-7974, thereby increasing IGFBP5 expression, the hsa_circ_0058122/miR-7974/IGFBP5 axis contributed to the Dex-mediated apoptosis. These findings may identify novel targets for SONFH molecular therap.
Other information
Title:

hsa_circ_0058122 knockdown prevents steroid-induced osteonecrosis of the femoral head by inhibiting human umbilical vein endothelial cells apoptosis via the miR-7974/IGFBP5 axis.

Journal: J Clin Lab Anal
Published: 2022/3/12
PubMed ID: 35274778