circRNA basic information
circBase ID: hsa_circ_0102273
Name: -
Synonym: circ_0102273
Host Gene: hsa-miR-1236-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human BC cells (SK-BR-3, MCF-7, MDA-MB-231, MDA-MB-453), normal breast epithelial cells (MCF10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1236-3p
Biological function: circ_0102273 was highly expressed in BC tumor tissues and cells, and its downregulation could inhibit BC cell proliferation, metastasis and glycolysis.
Molecular mechanism: hsa-miR-1236-3p was confirmed to be sponged by circ_0102273, and PFKFB3 could be targeted by hsa-miR-1236-3p, and its expression could be positively regulated by circ_0102273
Survival: -
Supported No.:
 1
Description:

In summary, our research proposed that circ_0102273 might be a potential target for BC treatment, which could inhibit BC proliferation, metastasis and glycolysis through the miR-1236-3p/PFKFB3 axis.
Other information
Title:

Knockdown of circ_0102273 inhibits the proliferation, metastasis and glycolysis of breast cancer through miR-1236-3p/PFKFB3 axis.

Journal: Anticancer Drugs
Published: 2022/3/11
PubMed ID: 35266884