circRNA basic information
circBase ID: -
Name: mmu_circ_Maml2
Synonym: CircRNA_Maml2
Host Gene: mmu-miR-93-3p
 
 
 
Disease basic information
DO ID:
 37
DO name: skin disease
Disease details: injury and repair of intestinal mucosa
Species: mouse
Species details: mouse
Sample type: PDX
Sample type details: mouse CT26.wt cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: mmu-miR-93-3p
Biological function: overexpression of circRNA_Maml2 promoted the proliferation and migration of CT26.wt cells_n vivo_nd the repair of damaged intestinal mucosa_n vitro.
Molecular mechanism: CircRNA_Maml2 acted as a sponge adsorption molecule for mmu-miR-93-3p to enhance the expression of frizzled class receptor 7 and activate the downstream Wnt/beta-catenin pathway, thereby promoting the repair of the intestinal mucosa.
Survival: -
Supported No.:
 1
Description:

Our findings demonstrate that circRNA_Maml2 regulates the miR-93-3p/FZD7/Wnt/beta-catenin pathway and promotes the repair of damaged intestinal mucosa. Hence, circRNA_Maml2 is a potential therapeutic target to promote intestinal mucosal repair.
Other information
Title:

CircRNA_Maml2 promotes the proliferation and migration of intestinal epithelial cells after severe burns by regulating the miR-93-3p/FZD7/Wnt/beta-catenin pathway.

Journal: Burns Trauma
Published: 2022/3/11
PubMed ID: 35265724