circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: circ-CCDC66
Host Gene: hsa-miR-129-5p
 
 
 
Disease basic information
DO ID:
 3969
DO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human thyroid cell line (Nttry-ori-3-1), PTC cell lines IHH4, BCPAP, K1, TPC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-129-5p
Biological function: In vitro_xperiments demonstrated that knockdown of circ-CCDC66 markedly suppressed the proliferative, migratory, and invasive capacities of PTC cells.
Molecular mechanism: hsa-miR-129-5p was a target gene of circ-CCDC66 and was downregulated in PTC tissues. LARP1, a downstream target of hsa-miR-129-5p, was upregulated in PTC tissues.
Survival: poor
Supported No.:
 1
Description:

Circ-CCDC66 promoted PTC proliferation, migration, invasion, and tumor growth by sponging miR-129-5p and promoting LARP1 expression.
Other information
Title:

Circular RNA coiled-coil domain containing 66 regulates malignant development of papillary thyroid carcinoma by upregulating La ribonucleoprotein 1 via the sponge effect on miR-129-5p.

Journal: Bioengineered
Published: 2022/3/11
PubMed ID: 35264065