circRNA basic information
circBase ID: -
Name: hsa_circ_HNRNPU
Synonym: circHNRNPU
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9538
DO name: multiple myeloma
Disease details: multiple myeloma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human MM cell lines (ARP1, CAG, HEK-293)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Everexpressed circHNRNPU_603aa promoted MM cell proliferation in vitro and in vivo, in contrast knockdown of circHNRNPU_603aa by siRNA abrogated these effects.
Molecular mechanism: Due to circHNRNPU_603aa including RNA-binding RGG-box region, it regulated SKP2 exon skipping, thereby competitively inhibited c-Myc ubiquitin so as to stabilize c-Myc in MM. MM cells secreted circHNRNPU through exosomes to interfere with various cells in the BM microenvironment.
Survival: poor
Supported No.:
 1
Description:

Our findings demonstrate that circHNRNPU_603aa is a promising diagnostic and therapeutic marker in both MM cells and BM niche.
Other information
Title:

A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing.

Journal: J Exp Clin Cancer Res
Published: 2022/3/10
PubMed ID: 35260179