circRNA basic information
circBase ID: -
Name: hsa_circ_SETD2
Synonym: circSETD2
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human liver cancer cell lines (HB611, SMMC-7721, HepG2, Hep3B, MHCC97L), human normal liver cells (L02)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circSETD2 knockdown can considerably increase liver cancer cells invasion, proliferation and colony formation.
Molecular mechanism: circSETD2 knockdown can considerably promote E-cadherin expression and inhibit Vimentin, N-cadherin, matrix metallopeptidase-9 (MMP-9) and MMP-2 expression.
Survival: -
Supported No.:
 1
Description:

These findings improve our understanding of the mechanisms of liver cancer progression and will guide future development of therapeutic strategies against the disease by targeting circ-SETD2.
Other information
Title:

Circular RNA circ SET domain containing 2 (circSETD2) inhibits hepatocellular carcinoma cell proliferation and invasion in vivo and in vitro.

Journal: Bioengineered
Published: 2022/3/10
PubMed ID: 35260047