circRNA basic information
circBase ID: hsa_circ_0037866
Name: -
Synonym: Circ_0037866
Host Gene: hsa-miR-384
 
 
 
Disease basic information
DO ID:
 4450
DO name: renal cell carcinoma
Disease details: renal cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human cell line (HK-2), RCC cell lines (A498, 786-O, 769-P)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-384
Biological function: circ_0037866 silencing suppressed RCC cell survival, invasion, and migration in vitro, and impeded RCC cell tumorigenesis in the subcutaneous xenograft model.
Molecular mechanism: circ_0037866 could function as a sponge for hsa-miR-384 to elevate the expression of its target CBX5.
Survival: -
Supported No.:
 1
Description:

Circ_0037866 knockdown restrains the tumorigenesis of RCC by miR-384/CBX5, revealing a promising molecular target for RCC therapy.
Other information
Title:

Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression.

Journal: Kidney Blood Press Res
Published: 2022/3/7
PubMed ID: 35249038