circRNA basic information
circBase ID: -
Name: hsa_circ_RASSF2
Synonym: CircRASSF2
Host Gene: hsa-miR-6838-5p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human osteoblast (hFOB1.19), OS cell lines (SAOS-2, U2OS , HOS, 293T)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-6838-5p
Biological function: Overexpression of circRASSF2 not only promoted the malignant biological behavior of OS cells
Molecular mechanism: circRASSF2 targeted hsa-miR-6838-5p, and promoted the expression of IGF1R
Survival: -
Supported No.:
 1
Description:

In conclusion, the promoting effects of IGF1R on OS are targeted by miR-6838-5p. CircRASSF2 restored the expression of IGF1R by sponging miR-6838-5p, thereby promoting the progression of OS.
Other information
Title:

CircRASSF2 promotes IGF1R and osteosarcoma metastasis via sponging miR-6838-5p.

Journal: Ann Transl Med
Published: 2022/3/5
PubMed ID: 35242856