circRNA basic information
circBase ID: -
Name: -
Synonym: circ_002172
Host Gene: hsa-miR-296-5p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human BC cell lines (MDA-MB-157, MDA-MB-231, MDA-MB-468, MDA-MB-453, MCF-7, HCC1954, HCC1806, Hs578T), mouse BC cell line (4 T1), human normal breast epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-296-5p
Biological function: Upregulation of circ_002172 and CXCL12 and downregulation of miR-296-5p occurred in BC tissues and cells. Circ_002172 promoted the oncogenic phenotypes of BC cells in vitro and growth of tumors in vivo, which was reversed by knockdown of CXCL12 expression.
Molecular mechanism: Circ_002172, as a hsa-miR-296-5p sponge, upregulated expression CXCL12.
Survival: -
Supported No.:
 1
Description:

Moreover, Ectopic expression of circ_002172 inhibited cytotoxic T lymphocytes (CTL) infiltration to promote the immune escape of BC. In conclusion, the tumor-promoting role of circ_002172 in BC was achieved by inducing immune escape via the miR-296-5p/CXCL12 axis.
Other information
Title:

Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis.

Journal: Int Immunopharmacol
Published: 2022/3/4
PubMed ID: 35240495