circRNA basic information
circBase ID: hsa_circ_0011385
Name: hsa_circ_EIF3I
Synonym: -
Host Gene: hsa-miR-149-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: 293T cells, human umbilical vein endothelial cells (HUVECs), human cervical epithelial immortalized cells H8, CC cells (HeLa, SiHa)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-149-5p
Biological function: Hsa_circ_0011385 knockdown reduced tumor growth in vivo and facilitated apoptosis, cell cycle arrest, impeded proliferation, metastasis, invasion, and angiogenesis of CC cells in vitro.
Molecular mechanism: Hsa_circ_0011385 could mediate PRDX6 expression through binding to hsa-miR-149-5p.
Survival: poor
Supported No.:
 2
Description:

In conclusion, hsa_circ_0011385 accelerated angiogenesis and malignant behaviors of CC cells by regulating the miR-149-5p/PRDX6 axis, manifesting that hsa_circ_0011385 might be a therapeutic target for CC.
Other information
Title:

Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149-5p and increasing PRDX6 expression.

Journal: Reprod Biol
Published: 2022/3/4
PubMed ID: 35240453