circRNA basic information
circBase ID: -
Name: hsa_circ_PRKCI
Synonym: circPRKCI
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BC cell lines (MDA-MB-231, BT-549), normal breast epithelial cell lines (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-545-3p
Biological function: The functional investigation showed that circPRKCI could significantly promote the proliferation and migration of TNBC in vivo and in vitro.
Molecular mechanism: circPRKCI regulated WBP2 and the phosphorylation of AKT via serving as hsa-miR-545-3p sponge.
Survival: -
Supported No.:
 1
Description:

Taken together, EIF4A3-mediated circPRKCI could promote TNBC progression by regulating WBP2 and PI3K/AKT signaling pathway, providing a new avenue of therapy for TNBC.
Other information
Title:

EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway.

Journal: Cell Death Discov
Published: 2022/3/4
PubMed ID: 35236829