circRNA basic information
circBase ID: hsa_circ_0085315
Name: -
Synonym: Circ_0085315
Host Gene: hsa-miR-1200
 
 
 
Disease basic information
DO ID:
 219
DO name: colon cancer
Disease details: colon cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human colon cancer cell lines (SW480, LOVO), normal colon epithelial cells (HCoEpic)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1200
Biological function: CircRNA_0085315 sponged miR-1200 to promote cell proliferation, migration, and invasion and affected the expression of Ki67, MMP2, E-cadherin, and N-cadherin
Molecular mechanism: circRNA_0085315 increased the phosphorylation levels of JNK, p38, and ERK1/2 by stimulating MAP3K1 up-regulation caused by hsa-miR-1200 inhibition
Survival: poor
Supported No.:
 1
Description:

In conclusion, circRNA_0085315 serves as a ceRNA and promotes CC progression through the activation of the MAPK signaling pathway mediated via the miR-1200/MAP3K1 axis, suggesting that circRNA_0085315 may be a promising diagnostic and therapeutic target for CC.
Other information
Title:

Circ_0085315 promotes cell proliferation, invasion, and migration in colon cancer through miR-1200/MAP3K1 signaling pathway.

Journal: Cell Cycle
Published: 2022/3/2
PubMed ID: 35230926