circRNA basic information
circBase ID: -
Name: hsa_circ_AXL
Synonym: CircAXL
Host Gene: hsa-miR-1306-5p
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: SK-N-SH cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1306-5p
Biological function: circAXL knockdown alleviated Abeta1-42-induced cell cytotoxicity, cell apoptosis, inflammation, oxidative stress and endoplasmic reticulum (ER) stress in SK-N-SH cells.
Molecular mechanism: hsa-miR-1306-5p was screened as a target of circAXL, and hsa-miR-1306-5p inhibition abolished the effects of circAXL knockdown. hsa-miR-1306-5p inhibited the expression of PDE4A, and circAXL regulated PDE4A expression by targeting hsa-miR-1306-5p.
Survival: -
Supported No.:
 3
Description:

Exosomal circAXL and exosomal miR-1306-5p had diagnostic values for AD. CircAXL knockdown alleviates Abeta1-42-induced neurotoxicity in AD pathology via repressing PDE4A by releasing miR-1306-5p.
Other information
Title:

CircAXL Knockdown Alleviates Abeta(1-42)-Induced Neurotoxicity in Alzheimer Disease via Repressing PDE4A by Releasing miR-1306-5p.

Journal: Neurochem Res
Published: 2022/3/2
PubMed ID: 35229272