circRNA basic information
circBase ID: -
Name: hsa_circ_SHKBP1
Synonym: circSHKBP1
Host Gene: hsa-miR-1294
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human normal lung epithelial cell line HBE (HBE), human lung cancer cell lines (A549, PC9, H1650, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1294
Biological function: Exosomal circSHKBP1 enhanced the proliferation, migration, invasion, and stemness of NSCLC cells.
Molecular mechanism: miRNA-1294 was identified as a target for circSHKBP1, and circSHKBP1 upregulated PKM2 expression by sponging hsa-miR-1294.
Survival: poor
Supported No.:
 1
Description:

Thus, exosomal circSHKBP1 participated in the progression of NSCLC via the miR-1294/PKM2 axis. circSHKBP1 may be potential biomarker for the diagnosis and treatment of NSCLC.
Other information
Title:

Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis.

Journal: Mol Ther Oncolytics
Published: 2022/3/2
PubMed ID: 35229026