circRNA basic information
circBase ID: hsa_circ_0086722
Name: -
Synonym: circ_0086722
Host Gene: hsa-miR-339-5p
 
 
 
Disease basic information
DO ID:
 10283
DO name: prostate cancer
Disease details: prostate cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PCa cell lines (VCaP, LNCaP, 22RV1, PC3, C4-2, DU145), normal prostate epithelial cell lines (RWPE-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-339-5p
Biological function: functional experiments revealed that circ_0086722 accelerated PCa proliferation and progression.
Molecular mechanism: circ_0086722 could mechanistically relieve the repressive effects of hsa-miR-339-5p on its target STAT5A
Survival: poor
Supported No.:
 1
Description:

In conclusion, our findings revealed that circ_0086722 drives PCa development via the miR-339-5p/STAT5A axis, and it may function as a potential prognostic biomarker or therapeutic target for PCa treatment. Further studies with large sample sizes and sufficiently long follow-up periods are necessary to confirm the predictive role of circ_0086722 for the prognosis of PCa patients.
Other information
Title:

Novel circular RNA circ_0086722 drives tumor progression by regulating the miR-339-5p/STAT5A axis in prostate cancer.

Journal: Cancer Lett
Published: 2022/3/2
PubMed ID: 35227787