circRNA basic information
circBase ID: -
Name: hsa_circ_CAMSAP1
Synonym: circCAMSAP1
Host Gene: -
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NPC cell lines (CNE2, HONE1, HNE2, HK1, CNE1, 5-8F, HNE1, 6-10B, C666-1), immortalized nasopharyngeal epithelial cell line (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promoted NPC proliferation and metastasis
Molecular mechanism: circCAMSAP1 promoted SERPINH1 expression through improved SERPINH1 mRNA stability by binding to the 3-untranslated region (3UTR) of SERPINH1.
Survival: -
Supported No.:
 1
Description:

Our findings revealed that circCAMSAP1 promotes NPC proliferation and metastasis by binding to the 3UTR of SERPINH1, suggesting that the positive feedback of circCAMSAP1-SERPINH1-c-Myc may serve as a prognostic biomarker or therapeutic target in patients with NPC.
Other information
Title:

Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop.

Journal: Mol Cancer
Published: 2022/3/2
PubMed ID: 35227262