circRNA basic information
circBase ID: -
Name: hsa_circ_PKD2
Synonym: Circ-PKD2
Host Gene: hsa-miR-646
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OSCC cell lines (SCC-15, CAL-27)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-646
Biological function: Overexpression of circ-PKD2 increased the formation of autophagosomes in OSCC cells and activation of proteins, such as LC3 II/I.
Molecular mechanism: circ-PKD2 promoted the expression of ATG13 by adsorption of hsa-miR-646.
Survival: -
Supported No.:
 2
Description:

This study provides a theoretical basis for using circ-PKD2 as a target to regulate the sensitivity of OSCC patients to cisplatin, thus increasing its chemotherapeutic effects.
Other information
Title:

Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.

Journal: Cell Death Dis
Published: 2022/2/28
PubMed ID: 35220397