circRNA basic information
circBase ID: -
Name: hsa_circ_CDK14
Synonym: circ-CDK14
Host Gene: hsa-miR-198
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human OS cell lines (MG63, HOS, U2OS, Saos-2), osteoblast cells (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-198
Biological function: Circ-CDK14 silencing suppressed OS cell viability, migration, invasion, and glycolysis and promoted cell apoptosis in vitro, as well as diminished tumor growth in vivo.
Molecular mechanism: circ-CDK14 directly targeted hsa-miR-198. Moreover, hsa-miR-198 was a functional mediator of circ-CDK14 in regulating OS cell progression in vitro. E2F2 was a direct target of hsa-miR-198, and hsa-miR-198 overexpression regulated OS cell progression in vitro by down-regulating E2F2.
Survival: -
Supported No.:
 5
Description:

Our findings demonstrate the inhibitory effect of circ-CDK14 silencing on OS progression by targeting the miR-198/E2F2 axis, establishing a strong rationale for decreasing circ-CDK14 as a novel therapeutic strategy for OS.
Other information
Title:

Silencing of circ-CDK14 suppresses osteosarcoma progression through the miR-198/E2F2 axis.

Journal: Exp Cell Res
Published: 2022/2/27
PubMed ID: 35218724