circRNA basic information
circBase ID: hsa_circ_0008896
Name: hsa_circ_PPAPDC1A
Synonym: -
Host Gene: hsa-miR-633
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human vascular smooth muscle cells (VSMCs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-633
Biological function: knockdown of hsa_circ_0008896 decreased proliferation, migration, and invasion of VSMCs.
Molecular mechanism: hsa_circ_0008896 functionally bound to hsa-miR-633. At last, combining bioinformatics and experimental analyses, we found the protein target of hsa_circ_0008896/hsa-miR-633, CDC20B (cell division cycle 20B).
Survival: -
Supported No.:
 1
Description:

Taken together, hsa_circ_0008896 regulated the expression of CDC20B by sponging hsa-miR-633, and then enhanced proliferation, migration, and invasion of VSMCs to promote the progression of atherosclerosis.
Other information
Title:

Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis.

Journal: Bioengineered
Published: 2022/2/26
PubMed ID: 35212610