circRNA basic information
circBase ID: -
Name: hsa_circ_LRP6
Synonym: circ_LRP6
Host Gene: hsa-miR-141-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human osteoblast cells (hFOB1.19), OS cell lines (MG63, U-2OS, HOS, SaOS-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-141-3p
Biological function: Functional assays revealed that circ_LRP6 knockdown inhibited the proliferation, migration and invasion of OS cells, whereas the inhibition of miR_141_3p or the overexpression of either HDAC4 or HMGB1 partly reversed the inhibitory effect of circ_LRP6 knockdown.
Molecular mechanism: circ_LRP6 negatively regulated the expression of miR_141_3p and, in turn, miR_141_3p negatively regulated HDAC4 and HMGB1 expression.
Survival: -
Supported No.:
 2
Description:

In summary, the present study determined that circ_LRP6 knockdown inhibited the proliferation, migration and invasion of OS cells by regulating the miR_141_3p/HDAC4/HMGB1 axis.
Other information
Title:

circ_LRP6 contributes to osteosarcoma progression by regulating the miR_141_3p/HDAC4/HMGB1 axis.

Journal: Int J Oncol
Published: 2022/2/26
PubMed ID: 35211755