circRNA basic information
circBase ID: -
Name: hsa_circ_BFAR
Synonym: circBFAR
Host Gene: hsa-miR-548b
 
 
 
Disease basic information
DO ID:
 3073
DO name: brain glioblastoma multiforme
Disease details: glioblastoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal human astrocytes (NHA), human glioma cell lines (U251, T98G, LN229, A172, SHG44)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-548b
Biological function: Knockdown of circBFAR inhibited proliferation and invasion both in vitro and in vivo.
Molecular mechanism: hsa-miR-548b was a direct target of circBFAR, and hsa-miR-548b may negatively regulate the expression of FoxM1.
Survival: poor
Supported No.:
 1
Description:

In conclusion, the present study demonstrated that a circBFAR/miR-548b/FoxM1 axis regulates the development of GBM and highlights potentially novel therapeutic targets for the treatment of GBM.
Other information
Title:

Circular RNA circBFAR promotes glioblastoma progression by regulating a miR-548b/FoxM1 axis.

Journal: FASEB J
Published: 2022/2/25
PubMed ID: 35202487