circRNA basic information
circBase ID: -
Name: -
Synonym: circ_0001459
Host Gene: hsa-miR-6165
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human HCC cell lines (HepG2, Huh7, Hep_3B, SK_HEP_1, SMMC7721), immortalized human hepatocyte cell line (LO2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-6165
Biological function: in vitro and in vivo functional experiments were carried out to detect the effects of circ_0001459 on HCC growth and metastasis._nockdown of circ_0001459 significantly inhibited the proliferation, migration, and invasion of HCC cells, whereas upregulation of circ_0001459 had the opposite effect.
Molecular mechanism: circ_0001459 could sponge hsa-miR-6165 and induce the upregulation of its downstream target IGF1R
Survival: -
Supported No.:
 1
Description:

we revealed that circ_0001459 could sponge miR-6165 and induce the upregulation of its downstream target IGF1R, thus significantly promoting the progression of HCC. Therefore, circ_0001459 could be a new potential therapeutic target for HCC patients.
Other information
Title:

Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR-6165/IGF1R axis.

Journal: Ann N Y Acad Sci
Published: 2022/2/25
PubMed ID: 35199365