circRNA basic information
circBase ID: hsa_circ_0025033
Name: -
Synonym: Circ_0025033
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: OC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-532-3p
Biological function: Circ_0025033 knockdown lessened PTX resistance, suppressed migration/invasion and promoted apoptosis of PTX-resistant cells.
Molecular mechanism: circ_0025033 upregulated the expression of FOXM1 by targeting hsa-miR-532-3p, and circ_0025033 knockdown blocked the malignant activities of PTX-resistant OC cells by enriching hsa-miR-532-3p and suppressing FOXM1.
Survival: -
Supported No.:
 4
Description:

Circ_0025033 downregulation impaired PTX resistance and malignant activities of PTX-resistant OC cells by regulating the miR-532-3p/FOXM1 network.
Other information
Title:

Circ_0025033 deficiency suppresses paclitaxel resistance and malignant development of paclitaxel-resistant ovarian cancer cells by modulating the miR-532-3p/FOXM1 network.

Journal: Immunopharmacol Immunotoxicol
Published: 2022/2/25
PubMed ID: 35196944