circRNA basic information
circBase ID: hsa_circ_0110251
Name: -
Synonym: Circ_0110251
Host Gene: hsa-miR-3189-3p
 
 
 
Disease basic information
DO ID:
 8398
DO name: osteoarthritis
Disease details: osteoarthritis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: chondrocytes were extracted from normal cartilage tissues
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-3189-3p
Biological function: Circ_0110251 was downregulated in OA cartilage tissues and IL-1beta-induced chondrocytes. IL-1beta promoted the apoptosis and ECM degradation in chondrocytes, while circ_0110251 overexpression relieved the effects.
Molecular mechanism: Circ_0110251 functioned as the sponge for hsa-miR-3189-3p and SPRY1 served as the target gene of hsa-miR-3189-3p.
Survival: -
Supported No.:
 1
Description:

Circ_0110251 protected chondrocytes from IL-1beta-induced apoptosis and ECM degradation in OA_ia_ponging miR-3189-3p and elevating SPRY1.
Other information
Title:

Circ_0110251 overexpression alleviates IL-1beta-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis.

Journal: Autoimmunity
Published: 2022/2/25
PubMed ID: 35196925