circRNA basic information
circBase ID: -
Name: hsa_circ_SETD3
Synonym: circSETD3
Host Gene: hsa-miR-147a
 
 
 
Disease basic information
DO ID:
 9261
DO name: nasopharynx carcinoma
Disease details: nasopharyngeal carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: NPC cell lines (SUNE1, CNE2, HNE1, C666), immortalized nasopharyngeal epithelial cell lines (NP69)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-147a
Biological function: Functional experiments revealed that circSETD3 knockdown inhibited NPC proliferation and increased DDP sensitivity and apoptosis rate. The promotion effect of circSETD3 overexpression on NPC proliferation and DDP resistance and inhibition effect on apoptosis was reversed by elevated miR-147a.
Molecular mechanism: circSETD3 knockdown or hsa-miR-147a overexpression prevented Akt/mTOR pathways activation.
Survival: -
Supported No.:
 2
Description:

In conclusion, the results of this study confirm that circSETD3 promotes NPC proliferation and DDP resistance by regulating miR-147a, and circSETD3/miR-147a axis may serve as a potential therapeutic target for NPC in the future.
Other information
Title:

Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression.

Journal: Bioengineered
Published: 2022/2/24
PubMed ID: 35196205